Ontology highlight
ABSTRACT:
SUBMITTER: Shukla NM
PROVIDER: S-EPMC2957514 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20100921 22
Toll-like receptor (TLR)-7 agonists show prominent immunostimulatory activities. The synthesis of a TLR7-active N(1)-(4-aminomethyl)benzyl substituted imidazoquinoline 5d served as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. Fluorescence microscopy experiments show that the fluorescent analogues are internalized and distributed in the endosomal compartment. Flow cytometry experiments using whole human blood show differential partitioni ...[more]