A HLA-DRB supertype chart with potential overlapping peptide binding function.
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ABSTRACT:
SUBMITTER: Mohanapriya A
PROVIDER: S-EPMC2957767 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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A HLA-DRB supertype chart with potential overlapping peptide binding function.
Mohanapriya Arumugam A Nandagond Satish S Shapshak Paul P Kangueane Uma U Kangueane Pandjassarame P
Bioinformation 20100120 7
HLA-DRB alleles are class II alleles that are associated with CD4+ T-cell immune response. DRB alleles are polymorphic and currently there are about 622 named in the IMGT/HLA sequence database. Each allele binds short peptides with high sensitivity and specificity. However, it has been suggested that majority of HLA alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides showing distinct repertoires. Definition of DRB supertypes using bindin ...[more]
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