Unknown

Dataset Information

0

Cost-effectiveness of pharmaceutical-based pandemic influenza mitigation strategies.


ABSTRACT: We used a hybrid transmission and economic model to evaluate the relative merits of stockpiling antiviral drugs and vaccine for pandemic influenza mitigation. In the absence of any intervention, our base-case assumptions generated a population clinical attack rate of 31.1%. For at least some parameter values, population prepandemic vaccination strategies were effective at containing an outbreak of pandemic influenza until the arrival of a matched vaccine. Because of the uncertain nature of many parameters, we used a probabilistic approach to determine the most cost-effective strategies. At a willingness to pay of >A$24,000 per life-year saved, more than half the simulations showed that a prepandemic vaccination program combined with antiviral treatment was cost-effective in Australia.

SUBMITTER: Newall AT 

PROVIDER: S-EPMC2957998 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cost-effectiveness of pharmaceutical-based pandemic influenza mitigation strategies.

Newall Anthony T AT   Wood James G JG   Oudin Noemie N   MacIntyre C Raina CR  

Emerging infectious diseases 20100201 2


We used a hybrid transmission and economic model to evaluate the relative merits of stockpiling antiviral drugs and vaccine for pandemic influenza mitigation. In the absence of any intervention, our base-case assumptions generated a population clinical attack rate of 31.1%. For at least some parameter values, population prepandemic vaccination strategies were effective at containing an outbreak of pandemic influenza until the arrival of a matched vaccine. Because of the uncertain nature of many  ...[more]

Similar Datasets

| S-EPMC2570828 | biostudies-literature
| S-EPMC3621766 | biostudies-literature
| S-EPMC1458676 | biostudies-literature
| S-EPMC10619092 | biostudies-literature
| S-EPMC3606600 | biostudies-literature
| S-EPMC3037387 | biostudies-literature
| S-EPMC4532250 | biostudies-literature
| S-EPMC3637125 | biostudies-literature
| S-EPMC3428215 | biostudies-literature
| S-EPMC4045999 | biostudies-literature