Ontology highlight
ABSTRACT:
SUBMITTER: Yoon HY
PROVIDER: S-EPMC2959122 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Traffic (Copenhagen, Denmark) 20081008 12
Signaling through the EGF receptor is regulated by endocytosis. ARAP1 is a protein with Arf guanosine triphosphatase-activating protein (GAP) and Rho GAP domains. We investigated the role of ARAP1 in EGF receptor endocytic trafficking. Following EGF treatment of cells, ARAP1 rapidly and transiently associated with the edge of the cell and punctate structures containing Rab5, rabaptin 5 and EGFR but not early embryonic antigen 1 (EEA1). EGF associated with the ARAP1-positive punctate structures p ...[more]