Ontology highlight
ABSTRACT:
SUBMITTER: Davies BW
PROVIDER: S-EPMC2959132 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Davies Bryan W BW Köhrer Caroline C Jacob Asha I AI Simmons Lyle A LA Zhu Jianyu J Aleman Lourdes M LM Rajbhandary Uttam L UL Walker Graham C GC
Molecular microbiology 20100916 2
The UPF0054 protein family is highly conserved with homologues present in nearly every sequenced bacterium. In some bacteria, the respective gene is essential, while in others its loss results in a highly pleiotropic phenotype. Despite detailed structural studies, a cellular role for this protein family has remained unknown. We report here that deletion of the Escherichia coli homologue, YbeY, causes striking defects that affect ribosome activity, translational fidelity and ribosome assembly. Ma ...[more]