Ontology highlight
ABSTRACT:
SUBMITTER: Blandin SA
PROVIDER: S-EPMC2959166 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091001 5949
The ability of Anopheles gambiae mosquitoes to transmit Plasmodium parasites is highly variable between individuals. However, the genetic basis of this variability has remained unknown. We combined genome-wide mapping and reciprocal allele-specific RNA interference (rasRNAi) to identify the genomic locus that confers resistance to malaria parasites and demonstrated that polymorphisms in a single gene encoding the antiparasitic thioester-containing protein 1 (TEP1) explain a substantial part of t ...[more]