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9-Ethyl-3-(imidazo[1,2-a]pyrimidin-3-yl)-9H-carbazole.

ABSTRACT: The title compound, C(20)H(16)N(4), is a precursor for the production of electron-transporting and -emitting materials. The bond lengths and angles in this compound are normal. In the crystal structure, there are no significant hydrogen-bonding inter-actions or π-π stacking inter-actions between mol-ecules.

SUBMITTER: Huang PH

PROVIDER: S-EPMC2959935 | biostudies-literature |

REPOSITORIES: biostudies-literature

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(Z)-9-(1,2-Dichloro-vin-yl)-9H-carbazole.

Project description:There are two independent mol-ecules in the asymmetric unit of the title compound, C14H9Cl2N, in which the dihedral angles between the dichloro-vinyl unit (r.m.s. deviations = 0.0003 and 0.0009 Å), and the carbazole ring are 87.77 (3) and 72.90 (3)°.

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9-Ethyl-3-(2-methyl-benzo-yl)-9H-carbazole.

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9-Ethyl-3,6-bis-(1H-imidazol-1-yl)-9H-carbazole.

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Design, synthesis, and bio-evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives that disrupt mitochondrial homeostasis in human lung adenocarcinoma

Project description:Purpose:To further explore the possible molecular mechanism by which compound 5n induces A549 cell apoptosis, we analyzed global transcriptome alterations of A549 cells at certain time points (48 h) after compound 5n treatment using RNA-seq analysis. Methods: Differential expression analysis for mRNA was performed using R package edgeR. Differentially expressed RNAs with |log2(FC)| value >1 and q value <0.05, considered as significantly modulated, were retained for further analysis. This choice is motivated by the decision to maximize the sensitivity of this analysis, in order to perform a massive screening and identify candidate genes to be validated with a wider sample population with real-time PCR analysis Results: The quantity of gene expression was calculated by FPKM (Fragments Per Kilobase of transcript per Million fragments mapped). Genes with log2 (Fold change) >1 and P value < 0.05 were considered as differentially expressed genes (DEGs). There were 146 upregulated genes and 158 downregulated genes for a total of 304 DEGs that were results are shown in Fig. 8A. Furthermore, the enriched KEGG pathways were analyzed and the top 30 pathways involved in these 304 DEGs between the two groups are shown in Figure SI. Among the top 30 pathways, 9 pathways related to mitochondrial function had significant effects. 37 DEGs in KEGG pathway associated with mitochondrial function was conducted and analyzed. Conclusions: Metabolism-related pathways was affected by compound 5n according the RNA-seq analysis

2022-07-01 | GSE190682 | GEO

9-Ethyl-3,6-bis-(5-iodo-2-thien-yl)-9H-carbazole.

Project description:In the title compound, C(22)H(15)I(2)NS(2), the two thio-phene rings are twisted out of the plane of the central pyrrole ring, making dihedral angles of 32.4 (2)° and 9.8 (2). In the crystal, neighboring mol-ecules are linked into centrosymmetric dimers by pairs of C-H⋯I inter-actions.

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Project description:The structure of the title compound, C(16)H(13)NO(2), was determined as a part of a project on the synthesis of new compounds which can make two-photon absorptions. In the crystal structure, both aldehyde groups are located within the carbazole plane. One of these groups is disordered and was refined using a split model with site-occupation factors for each position of 0.5.

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Project description:The supra-molecular structure of the title compound, C(9)H(11)N(3)O(3)S(2), is defined by two inter-molecular hydrogen bonds. Pairs of N-H⋯N hydrogen bonds link the mol-ecules into centrosymmetric dimers and N-H⋯O hydrogen bonds link the dimers into a tubular chain structure running parallel to the a axis.

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1,2-Dihydro-9H-carbazole-4(3H)-thione.

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| S-EPMC3100014 | biostudies-literature

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