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Trichodermin (4β-acet-oxy-12,13-epoxy-trichothec-9-ene).

ABSTRACT: In the title natural product, C(17)H(24)O(4), which is a very potent inhibitor of protein synthesis in mammalian cells, the five-membered ring displays an envelope conformation, whereas the two six-membered rings show different conformations, viz. chair and half-chair.

SUBMITTER: Chen SY

PROVIDER: S-EPMC2960951 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Dihalogenated trichodermin (4?-acet-oxy-9,10-dibromo-12,13-epoxy-tri-chothec).

Project description:In the title dihalogenated trichodermin mol-ecule, C(17)H(24)Br(2)O(4) (systematic name: 9,10-dibromo-12,13-epoxy-trichothec-9-en-4?-yl acetate), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show the same conformation, viz. chair. As for the seven-membered ring, the dihedral angle between the mean planes formed by the four C atoms of the envelope unit and the three C and one O atoms of the six-membered chair is 69.08?(4)°; these two mean planes are nearly perpendicular to the ep-oxy ring with angles of 87.53?(4) and 88.67?(4)°, respectively.

| S-EPMC2980171 | biostudies-literature

Trichodermol (4?-hydr-oxy-12,13-epoxy-trichothec-9-ene).

Project description:In the title compound, C(15)H(22)O(3), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show different conformations, viz. chair and half-chair. In the crystal, mol-ecules are linked through inter-molecular O-H?O hydrogen bonds, forming chains running along the b axis.

| S-EPMC2971347 | biostudies-literature

Trichodermin (12,13-ep-oxy-trichethec-9-en-4?-yl 4-fluoro-benzoate).

Project description:IN THE TITLE TRICHODERMIN COMPOUND (SYSTEMATIC NAME: 12,13-ep-oxy-trichothec-9-en-4?-yl 4-fluoro-benzoate), C(22)H(25)FO(4), the five-membered ring displays an envelope conformation, whereas the two six-membered rings show the different conformations, viz. chair and half-chair. As for the seven-membered ring, the dihedral angle between the mean planes formed by the four C atoms of the envelope unit and the three C and one O atoms of the six-membered chair is 68.67?(2)°; these two mean planes are nearly perpendicular to the ep-oxy ring with angles of 87.97?(2)and 88.14?(2)°, respectively.

| S-EPMC3007378 | biostudies-literature

4?-Hy-droxy-12,13-ep-oxy-trichothec-9-ene.

Project description:The asymmetric unit in the crystal of the title compound, C(15)H(22)O(3), contains two independent mol-ecules with similar structures. Each mol-ecule contains two six-membered rings and one five-membered ring. The five-membered ring displays an envelope conformation with the C atom linking the epoxy group as the flap, while the two six-membered rings show half-chair conformations. The two independent mol-ecules are linked by an O-H?O hydrogen bond. These dimers are further linked by O-H?O hydrogen bonds, forming supra-molecular chains running along the a axis.

| S-EPMC3344132 | biostudies-literature

6β-Acet-oxy-1α,7β,11β,15β-tetra-hydr-oxy-7α,20-ep-oxy-ent-kaur-16-ene.

Project description:The title compound, C(22)H(32)O(7), a natural ent-kaurane diterpenoid also referred to as Maoyecrystal F, was obtained from the medicinal plant Isodon nervosa. There are four rings with the expected cis and trans junctions. Cyclohexane ring A adopts a chair conformation, rings B and C adopt boat conformations, while the five-membered ring has an envelope conformation. The mol-ecules stack along the a axis in the crystal and are linked together by inter-molecular O-H⋯O hydrogen bonds.

| S-EPMC2979918 | biostudies-literature

Poly[(?-2-acet-oxy-benzoato)(2-acet-oxy-benzoato)-?-aqua-mercury(II)].

Project description:In the title compound, [Hg(C(9)H(7)O(4))(2)(H(2)O)](n), the Hg(II) ion is five-coordinated by three acetylsalicylate anions and water leading to the formation of a coordination polymer extending parallel to (001). O-H?O and C-H?O hydrogen bonds are effective in the stabilization of the crystal structure.

| S-EPMC3212253 | biostudies-literature

Acet-oxy-γ-valerolactone.

Project description:Levulinyl cellulose esters have been produced as an effective renewable binder for architectural coatings. The title compound, C7H10O4 (systematic name: 2-methyl-5-oxo-tetra-hydro-furan-2-yl acetate), assigned as the esterifying species, was isolated and crystallized to confirm the structure. In the crystal, the mol-ecules pack in layers parallel to (102) utilizing weak C-H⋯O inter-actions.

| S-EPMC3685093 | biostudies-literature

17?-Acet-oxy-11?-hy-droxy-6?-methyl-pregn-4-ene-3,20-dione.

Project description:The title compound, C(24)H(34)O(5), a fungal-transformed metabolite of the injecta-ble contraceptive medroxyprogesterone acetate, consists of four fused rings (A, B, C and D; steroid labelling). Ring A exists in a half-chair conformation while trans-fused rings B and C adopt chair conformations. The five-membered ring D adopts an envelope conformation with the C atom bound to the methyl group at the flap. In the crystal, adjacent mol-ecules are linked by O-H?O and C-H?O hydrogen bonds, forming infinite chains along the a axis.

| S-EPMC3393278 | biostudies-other

catena-Poly[(diaqua-cadmium)-?-4,4'-[sulfonyl-bis-(1,4-phenyl-ene-oxy)]-di-acet-ato-?O,O':O'',O'''].

Project description:In the title coordination polymer, [Cd(C(16)H(12)O(8)S)(H(2)O)(2)](n), the Cd(II) ion is situated on a crystallographic twofold rotation axis, being coordinated by four O atoms from two bidentate 4,4'-[sulfonyl-bis-(1,4-phenyl-ene-oxy)]diacetate (L) ligands and two water mol-ecules in a highly distorted CdO(6) octa-hedral geometry. Each complete ligand L, which is also generated by twofold symmetry with the S atom lying on the rotation axis, bridges two Cd(II) atoms to form a polymeric zigzag chain propagating in the [10-1] direction. O-H?O hydrogen bonds between the coordinated water mol-ecules and carboxyl-ate O atoms are involved in the packing.

| S-EPMC3297229 | biostudies-literature

9?-Acet-oxy-1?,10?-ep-oxy-parthenolide.

Project description:The title compound, C(17)H(22)O(6), was semi-synthesized from 9-hy-droxy-arthenolide, which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The mol-ecule contains fused five- and ten-membered rings: the five-membered lactone ring has a twisted conformation, whereas the ten-membered ring displays an approximate chair-chair conformation. The dihedral angle between the rings is 24.76?(9)°.

| S-EPMC3011600 | biostudies-literature

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