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N-(3-Oxo-1-thia-4-aza-spiro-[4.5]dec-4-yl)-6-phenyl-imidazo[2,1-b][1,3]thia-zole-3-acetamide hemihydrate.

ABSTRACT: The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two mol-ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16?(9) and 21.37?(9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two mol-ecules are stabilized by intra-molecular N-H?O, O-H?O and C-H?S inter-actions and the crystal structure is stabilized by inter-molecular N-H?O, O-H?O, C-H?O and C-H?N inter-actions.

SUBMITTER: Akkurt M

PROVIDER: S-EPMC2961240 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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N-(3-Oxo-1-thia-4-aza-spiro-[4.5]dec-4-yl)-6-phenyl-imidazo[2,1-b][1,3]thia-zole-3-acetamide hemihydrate.

Akkurt Mehmet M Yalçın Serife Pınar SP Güzeldemirci Nuray Ulusoy NU Büyükgüngör Orhan O

Acta crystallographica. Section E, Structure reports online 20080410 Pt 5

The title compound, C(21)H(22)N(4)O(2)S(2)·0.5H(2)O, crystallizes with two mol-ecules in the asymmetric unit. The dihedral angles between the phenyl and imidazothiazole ring systems are 19.16 (9) and 21.37 (9)°. In the imidazothiazole ring systems, the cyclohexane rings adopt chair conformations, while the thiazole rings have distorted envelope conformations. The two mol-ecules are stabilized by intra-molecular N-H⋯O, O-H⋯O and C-H⋯S inter-actions and the crystal structure is stabilized by inter ...[more]

PMID: 21202301

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