Ontology highlight
ABSTRACT:
SUBMITTER: Kok FO
PROVIDER: S-EPMC2962425 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20100201 2
Cell-type specific regulation of a small number of growth factor signal transduction pathways generates diverse developmental outcomes. The zinc finger protein Churchill (ChCh) is a key effector of fibroblast growth factor (FGF) signaling during gastrulation. ChCh is largely thought to act by inducing expression of the multifunctional Sip1 (Smad Interacting Protein 1). We investigated the function of ChCh and Sip1a during zebrafish somitogenesis. Knockdown of ChCh or Sip1a results in misshapen s ...[more]