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Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

ABSTRACT: The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.

SUBMITTER: Goulder PJ

PROVIDER: S-EPMC2963026 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Goulder Philip J R PJ Watkins David I DI

Nature reviews. Immunology 20080801 8

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, ...[more]

PMID: 18617886

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