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The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease.

ABSTRACT: Disorders of retinal vascular growth and function are responsible for vision loss in a variety of diseases, including diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity and retinal artery or vein occlusion. Over the past decade, a new signaling pathway that controls retinal vascular development has emerged from the study of inherited disorders - in both humans and mice - that are characterized by retinal hypovascularization. This pathway utilizes a glial-derived extracellular ligand, Norrin, that acts on a transmembrane receptor, Frizzled4, a coreceptor, Lrp5, and an auxiliary membrane protein, Tspan12, on the surface of developing endothelial cells. The resulting signal controls a transcriptional program that regulates endothelial growth and maturation. It will be of great interest to determine whether modulating this pathway could represent a therapeutic approach to human retinal vascular disease.

SUBMITTER: Ye X

PROVIDER: S-EPMC2963063 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease.

Ye Xin X Wang Yanshu Y Nathans Jeremy J

Trends in molecular medicine 20100803 9

Disorders of retinal vascular growth and function are responsible for vision loss in a variety of diseases, including diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity and retinal artery or vein occlusion. Over the past decade, a new signaling pathway that controls retinal vascular development has emerged from the study of inherited disorders - in both humans and mice - that are characterized by retinal hypovascularization. This pathway utilizes a glial-derived e ...[more]

PMID: 20688566

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Project description:This SuperSeries is composed of the SubSeries listed below.

2009-10-01 | GSE16841 | GEO

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