Ontology highlight
ABSTRACT:
SUBMITTER: Saleh AF
PROVIDER: S-EPMC2963316 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Saleh Amer F AF Arzumanov Andrey A Abes Rachida R Owen David D Lebleu Bernard B Gait Michael J MJ
Bioconjugate chemistry 20101001 10
Arginine-rich cell-penetrating peptides have found excellent utility in cell and in vivo models for enhancement of delivery of attached charge-neutral PNA or PMO oligonucleotides. We report the synthesis of dendrimeric peptides containing 2- or 4-branched arms each having one or more R-Ahx-R motifs and their disulfide conjugation to a PNA705 splice-redirecting oligonucleotide. Conjugates were assayed in a HeLa pLuc705 cell assay for luciferase up-regulation and splicing redirection. Whereas 8-Ar ...[more]