Ontology highlight
ABSTRACT:
SUBMITTER: Frank CL
PROVIDER: S-EPMC2963346 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Frank Christopher L CL Ge Xuecai X Xie Zhigang Z Zhou Ying Y Tsai Li-Huei LH
The Journal of biological chemistry 20100819 43
Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated post-translational modifications. In this study, we describe a novel mechanism controlling the persistence of the transcription factor ATF4 by multisite phosphorylation. Proline-directed phosphorylation acted additively to regulate multiple aspects of ATF4 degradation. Stabilized AT ...[more]