Ontology highlight
ABSTRACT:
SUBMITTER: Huang HP
PROVIDER: S-EPMC2963358 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Huang Hsiang-Po HP Yu Chun-Ying CY Chen Hsin-Fu HF Chen Pin-Hsun PH Chuang Ching-Yu CY Lin Sung-Jan SJ Huang Shih-Tsung ST Chan Wei-Hung WH Ueng Tzuu-Huei TH Ho Hong-Nerng HN Kuo Hung-Chih HC
The Journal of biological chemistry 20100818 43
The future clinical use of embryonic stem cell (ESC)-based hepatocyte replacement therapy depends on the development of an efficient procedure for differentiation of hepatocytes from ESCs. Here we report that a high density of human ESC-derived fibroblast-like cells (hESdFs) supported the efficient generation of hepatocyte-like cells with functional and mature hepatic phenotypes from primate ESCs and human induced pluripotent stem cells. Molecular and immunocytochemistry analyses revealed that h ...[more]