Ontology highlight
ABSTRACT:
SUBMITTER: Romero J
PROVIDER: S-EPMC2963641 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20080608 7
Faithful replication of the entire genome once per cell cycle is essential for maintaining genetic integrity, and the origin of DNA replication is key in this regulation. Unlike that in unicellular organisms, the replication initiation mechanism in mammalian cells is not well understood. We have identified a strong origin of replication at the DBF4 promoter locus, which contains two initiation zones, two origin recognition complex (ORC) binding sites and two DNase I-hypersensitive regions within ...[more]