Ontology highlight
ABSTRACT:
SUBMITTER: Fehniger TA
PROVIDER: S-EPMC2963822 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Fehniger Todd A TA Wylie Todd T Germino Elizabeth E Leong Jeffrey W JW Magrini Vincent J VJ Koul Sunita S Keppel Catherine R CR Schneider Stephanie E SE Koboldt Daniel C DC Sullivan Ryan P RP Heinz Michael E ME Crosby Seth D SD Nagarajan Rakesh R Ramsingh Giridharan G Link Daniel C DC Ley Timothy J TJ Mardis Elaine R ER
Genome research 20101008 11
Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g., granzyme B, GzmB) through unclear molecular mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate the translation of their mRNA targets, and are therefore candidates for mediating this control process. While the expr ...[more]