Ontology highlight
ABSTRACT:
SUBMITTER: Katzman SD
PROVIDER: S-EPMC2964228 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Katzman Shoshana D SD O'Gorman William E WE Villarino Alejandro V AV Gallo Eugenio E Friedman Rachel S RS Krummel Matthew F MF Nolan Garry P GP Abbas Abul K AK
Proceedings of the National Academy of Sciences of the United States of America 20101004 42
The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen recognition by CD4(+) T cells, we show, using single-cell biochemical analyses, that tolerance is characterized by transient signaling events downstream of T-cell receptor engagement in the mammalian target of rapamycin (mTOR) and NF-κB pathways. Parallel studies done by live cell imaging show that the key difference between tolerance and activa ...[more]