Ontology highlight
ABSTRACT:
SUBMITTER: Hailu A
PROVIDER: S-EPMC2964287 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hailu Asrat A Musa Ahmed A Wasunna Monique M Balasegaram Manica M Yifru Sisay S Mengistu Getahun G Hurissa Zewdu Z Hailu Workagegnehu W Weldegebreal Teklu T Tesfaye Samson S Makonnen Eyasu E Khalil Eltahir E Ahmed Osama O Fadlalla Ahmed A El-Hassan Ahmed A Raheem Muzamil M Mueller Marius M Koummuki Yousif Y Rashid Juma J Mbui Jane J Mucee Geoffrey G Njoroge Simon S Manduku Veronica V Musibi Alice A Mutuma Geoffrey G Kirui Fredrick F Lodenyo Hudson H Mutea Dedan D Kirigi George G Edwards Tansy T Smith Peter P Muthami Lawrence L Royce Catherine C Ellis Sally S Alobo Moses M Omollo Raymond R Kesusu Josephine J Owiti Rhoda R Kinuthia John J
PLoS neglected tropical diseases 20101026 10
<h4>Background</h4>Visceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease is fatal, available treatment is expensive and often toxic, and drug resistance is increasing. Improved treatment options are needed. Paromomycin was shown to be an efficacious first-line treatment with low toxicity in India.<h4>Methods</h4>This was a 3-arm multicentre, open-label, randomized, controlled clinical trial to compare three treatment regimens for VL in East Africa: ...[more]