Ontology highlight
ABSTRACT:
SUBMITTER: Hanel ML
PROVIDER: S-EPMC2964887 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Hanel Meredith L ML Wuebbles Ryan D RD Jones Peter L PL
Developmental dynamics : an official publication of the American Association of Anatomists 20090601 6
The leading candidate gene responsible for facioscapulohumeral muscular dystrophy (FSHD) is FRG1 (FSHD region gene 1). However, the correlation of altered FRG1 expression levels with disease pathology has remained controversial and the precise function of FRG1 is unknown. Here, we carried out a detailed analysis of the normal expression patterns and effects of FRG1 misexpression during vertebrate embryonic development using Xenopus laevis. We show that frg1 is expressed in and essential for the ...[more]