Ontology highlight
ABSTRACT:
SUBMITTER: Glynn SA
PROVIDER: S-EPMC2964971 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Glynn Sharon A SA Boersma Brenda J BJ Dorsey Tiffany H TH Yi Ming M Yfantis Harris G HG Ridnour Lisa A LA Martin Damali N DN Switzer Christopher H CH Hudson Robert S RS Wink David A DA Lee Dong H DH Stephens Robert M RM Ambs Stefan S
The Journal of clinical investigation 20101018 11
Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO) production affect the redox state of cells and can induce protein, lipid, and DNA modifications. To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors. In multivariable survival analysis, increased NOS2 predicted inferi ...[more]