Ontology highlight
ABSTRACT:
SUBMITTER: Mallevaey T
PROVIDER: S-EPMC2965025 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Mallevaey Thierry T Scott-Browne James P JP Matsuda Jennifer L JL Young Mary H MH Pellicci Daniel G DG Patel Onisha O Thakur Meena M Kjer-Nielsen Lars L Richardson Stewart K SK Cerundolo Vincenzo V Howell Amy R AR McCluskey James J Godfrey Dale I DI Rossjohn Jamie J Marrack Philippa P Gapin Laurent L
Immunity 20090701 1
Mouse type I natural killer T cell receptors (iNKT TCRs) use a single V alpha 14-J alpha 18 sequence and V beta s that are almost always V beta 8.2, V beta 7, or V beta 2, although the basis of this differential usage is unclear. We showed that the V beta bias occurred as a consequence of the CDR2 beta loops determining the affinity of the iNKT TCR for CD1d-glycolipids, thus controlling positive selection. Within a conserved iNKT-TCR-CD1d docking framework, these inherent V beta-CD1d affinities ...[more]