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Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.

ABSTRACT: Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC(50) = 3.70 ?M), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC(50) = 5.2 ?M), without appreciable cytotoxicity.

SUBMITTER: Pereira AR

PROVIDER: S-EPMC2965064 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.

Pereira Alban R AR Cao Zhengyu Z Engene Niclas N Soria-Mercado Irma E IE Murray Thomas F TF Gerwick William H WH

Organic letters 20101001 20

Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC(50) = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocki ...[more]

PMID: 20845912

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