Ontology highlight
ABSTRACT:
SUBMITTER: Coelmont L
PROVIDER: S-EPMC2965138 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Coelmont Lotte L Hanoulle Xavier X Chatterji Udayan U Berger Carola C Snoeck Joke J Bobardt Michael M Lim Precious P Vliegen Inge I Paeshuyse Jan J Vuagniaux Grégoire G Vandamme Anne-Mieke AM Vandamme Anne-Mieke AM Bartenschlager Ralf R Gallay Philippe P Lippens Guy G Neyts Johan J
PloS one 20101027 10
DEB025/Debio 025 (Alisporivir) is a cyclophilin (Cyp)-binding molecule with potent anti-hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in phase II clinical trials. DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication. Here we report that it was very difficult to select resistant replicons (genotype 1b) to DEB025, requiring an average of 20 weeks (four independent experiments), compared to the typi ...[more]