Ontology highlight
ABSTRACT:
SUBMITTER: Zhang AX
PROVIDER: S-EPMC2965167 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Zhang Andrew X AX Murelli Ryan P RP Barinka Cyril C Michel Julien J Cocleaza Alexandra A Jorgensen William L WL Lubkowski Jacek J Spiegel David A DA
Journal of the American Chemical Society 20100901 36
Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase overexpressed in many forms of prostate cancer. Our laboratory has recently disclosed a class of small molecules, called ARM-Ps (antibody-recruiting molecule targeting prostate cancer) that are capable of enhancing antibody-mediated immune recognition of prostate cancer cells. Interestingly, during the course of these studies, we found ARM-Ps to exhibit extraordinarily high potencies toward PSMA, compared to ...[more]