Ontology highlight
ABSTRACT:
SUBMITTER: Matsushima K
PROVIDER: S-EPMC2965190 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Matsushima Kentaro K Suyama Takashi T Takenaka Chiemi C Nishishita Naoki N Ikeda Keiko K Ikada Yoshito Y Sawa Yoshiki Y Jakt Lars Martin LM Mori Hajime H Kawamata Shin S
Tissue engineering. Part A 20100723 11
Expression of the Wnt modulator secreted frizzled related protein 4 (Sfrp4) is upregulated after heart ischemic injury. We show that intramuscular administration of recombinant Sfrp4 to rat heart ischemic injury and recanalization models prevents further deterioration of cardiac function after the ischemic injury. The effect of Sfrp4 persisted for at least 20 weeks when Sfrp4 was administered in a slow release system (Sfrp4-polyhedra) to both acute and subacute ischemic models. The histology of ...[more]