Ontology highlight
ABSTRACT:
SUBMITTER: Campa D
PROVIDER: S-EPMC2965729 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Campa Daniele D Hüsing Anika A McKay James D JD Sinilnikova Olga O Vogel Ulla U Tjønneland Anne A Overvad Kim K Stegger Jakob J Clavel-Chapelon Françoise F Chabbert-Buffet Nathalie N Fagherazzi Guy G Trichopoulou Antonia A Zylis Dimosthenis D Oustoglou Erifili E Rohrmann Sabine S Teucher Birgit B Fisher Eva E Boeing Heiner H Masala Giovanna G Krogh Vittorio V Sacerdote Carlotta C Panico Salvatore S Tumino Rosario R Onland-Moret N Charlotte NC van Gils Carla H CH Bueno-de-Mesquita H Bas HB Lund Eiliv E Chirlaque María Dolores MD Sala Núria N Quirós José Ramon JR Ardanaz Eva E Amiano Pilar P Molina-Montes Esther E Hallmans Göran G Lenner Per P Travis Ruth C RC Key Timothy J TJ Wareham Nick N Khaw Kay-Tee KT Rinaldi Sabina S Slimani Nadia N Chajes Veronique V Siddiq Afshan A Riboli Elio E Kaaks Rudolf R Canzian Federico F
BMC cancer 20101018
<h4>Background</h4>The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, wi ...[more]