Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC2966020 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Zhou Min M Zhang Rui R Huang Miao M Lu Wei W Song Shaoli S Melancon Marites P MP Tian Mei M Liang Dong D Li Chun C
Journal of the American Chemical Society 20101101 43
We synthesized and evaluated a novel class of chelator-free [(64)Cu]CuS nanoparticles (NPs) suitable both for PET imaging and as photothermal coupling agents for photothermal ablation. These [(64)Cu]CuS NPs are simple to make, possess excellent stability, and allow robust noninvasive micro-PET imaging. Furthermore, the CuS NPs display strong absorption in the near-infrared (NIR) region (peak at 930 nm); passive targeting prefers the tumor site, and mediated ablation of U87 tumor cells occurs upo ...[more]