Ontology highlight
ABSTRACT:
SUBMITTER: Rai G
PROVIDER: S-EPMC2966298 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20101001 20
There are a variety of lipoxygenases in the human body (hLO), each having a distinct role in cellular biology. Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the dioxygenation of 1,4-cis,cis-pentadiene-containing polyunsaturated fatty acids, is implicated in a number of diseases including cancer, atherosclerosis, and neurodegenerative conditions. Despite the potential therapeutic relevance of this target, few inhibitors have been reported that are both potent and selective. To ...[more]