Ontology highlight
ABSTRACT:
SUBMITTER: Daneman R
PROVIDER: S-EPMC2966423 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Daneman Richard R Zhou Lu L Agalliu Dritan D Cahoy John D JD Kaushal Amit A Barres Ben A BA
PloS one 20101029 10
The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and pathogens into the brain. Despite its importance, little is known about the molecular mechanisms regulating the development and function of this crucial barrier. In this study we have developed methods to highly purify and gene profile endothelial cells from different tissues, and by comparing the transcriptional profile of brain endothelial cells with those purified from the liver and lung, we have gene ...[more]