Ontology highlight
ABSTRACT:
SUBMITTER: Moon HR
PROVIDER: S-EPMC2967253 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Moon Hyung Ryong HR Siddiqui Maqbool A MA Sun Guangyu G Filippov Igor V IV Landsman Nicholas A NA Lee Yi-Chien YC Adams Kristie M KM Barchi Joseph J JJ Deschamps Jeffrey R JR Nicklaus Marc C MC Kelley James A JA Marquez Victor E VE
Tetrahedron 20100801 34
Steric and electronic parameters such as the anomeric effect (AE) and gauche effect play significant roles in steering the North ⇆ South equilibrium of nucleosides in solution. Two isomeric oxa-bicyclo[3.1.0]hexane nucleosides that are conformationally locked in either the North or the South conformation of the pseudorotational cycle were designed to study the consequences of having the AE operational or not, independent of other parameters. The rigidity of the system allowed the orientation of ...[more]