Ontology highlight
ABSTRACT:
SUBMITTER: Shen S
PROVIDER: S-EPMC2967389 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Shen Shuijie S Zhang Fan F Gao Lingbo L Zeng Su S Zheng Jiang J
Drug metabolism and disposition: the biological fate of chemicals 20100819 11
Metabolic activation is considered to be a critical step for styrene-induced pulmonary toxicity. Styrene-7,8-oxide is a primary oxidative metabolite generated by vinyl epoxidation of styrene. In addition, urinary 4-vinylphenol (4-VP), a phenolic metabolite formed by aromatic hydroxylation, has been detected in workers and experimental animals after exposure to styrene. In the present study, new oxidative metabolites of styrene, including 2-vinylphenol (2-VP), 3-vinylphenol (3-VP), vinyl-1,4-hydr ...[more]