Ontology highlight
ABSTRACT:
SUBMITTER: Fisher SZ
PROVIDER: S-EPMC2967421 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Fisher S Z SZ Kovalevsky A Y AY Domsic J J Mustyakimov M M Silverman D N DN McKenna R R Langan P P
Acta crystallographica. Section D, Biological crystallography 20101020 Pt 11
Carbonic anhydrase (CA) is a ubiquitous metalloenzyme that catalyzes the reversible hydration of CO(2) to form HCO(3)(-) and H(+) using a Zn-hydroxide mechanism. The first part of catalysis involves CO(2) hydration, while the second part deals with removing the excess proton that is formed during the first step. Proton transfer (PT) is thought to occur through a well ordered hydrogen-bonded network of waters that stretches from the metal center of CA to an internal proton shuttle, His64. These w ...[more]