Ontology highlight
ABSTRACT:
SUBMITTER: Singh N
PROVIDER: S-EPMC2968757 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100601 24
RNA interference (RNAi) is a cellular process whereby the silencing of a particular gene is mediated by short RNAs (siRNAs). Although siRNAs have great therapeutic potential, cellular delivery has been a challenge. Nanoparticle-siRNA conjugates have emerged as potential delivery vehicles; however, reports describing the effects of nanoparticle conjugation on RISC incorporation and subsequent gene silencing have been mixed. In this report, we have systematically evaluated the effect of siRNA coup ...[more]