Ontology highlight
ABSTRACT:
SUBMITTER: Appelbaum L
PROVIDER: S-EPMC2969179 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Appelbaum Lior L Wang Gordon G Yokogawa Tohei T Skariah Gemini M GM Smith Stephen J SJ Mourrain Philippe P Mignot Emmanuel E
Neuron 20101001 1
Neurons exhibit rhythmic activity that ultimately affects behavior such as sleep. In living zebrafish larvae, we used time-lapse two-photon imaging of the presynaptic marker synaptophysin in hypocretin/orexin (HCRT) neurons to determine the dynamics of synaptic modifications during the day and night. We observed circadian rhythmicity in synapse number in HCRT axons. This rhythm is regulated primarily by the circadian clock but is also affected by sleep deprivation. Furthermore, NPTX2, a protein ...[more]