Ontology highlight
ABSTRACT:
SUBMITTER: McDonald JT
PROVIDER: S-EPMC2970706 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
McDonald J Tyson JT McDonald J Tyson JT Kim Kwanghee K Norris Andrew J AJ Vlashi Erina E Phillips Tiffany M TM Lagadec Chann C Della Donna Lorenza L Ratikan Josephine J Szelag Heather H Hlatky Lynn L McBride William H WH
Cancer research 20101012 21
The transcription factor NF-E2-related factor 2 (Nrf2) binds the antioxidant DNA response element (ARE) to activate important cellular cytoprotective defense systems. Recently several types of cancers have been shown to overexpress Nrf2, but its role in the cellular response to radiation therapy has yet to be fully determined. In this study, we report that single doses of ionizing radiation from 2 to 8 Gy activate ARE-dependent transcription in breast cancer cells in a dose-dependent manner, but ...[more]