Protective efficacy of recombinant urease B and aluminum hydroxide against Helicobacter pylori infection in a mouse model.
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ABSTRACT:
SUBMITTER: Begue RE
PROVIDER: S-EPMC2970735 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Protective efficacy of recombinant urease B and aluminum hydroxide against Helicobacter pylori infection in a mouse model.
Bégué Rodolfo E RE Sadowska-Krowicka Halina H
FEMS immunology and medical microbiology 20100823 2
Efforts are underway for the development of an effective vaccine against Helicobacter pylori infection. We prepared recombinant full-length (568 aa) H. pylori recombinant urease B (rUreB) protein and tested it for immunogenicity and protection. BALB/c mice received either rUreB (40 μg) plus CpG (10 μg) intranasally, rUreB (50 μg) plus 3% aluminum hydroxide (50 μL) intramuscularly or rUreB (25 μg) plus Freund's adjuvant (25 μL) subcutaneously, three times (weeks 0, 2 and 6). Intranasal rUreB plus ...[more]
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