Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Alai MM
PROVIDER: S-EPMC2970912 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
García-Alai María M MM Allen Mark D MD Joerger Andreas C AC Bycroft Mark M
Protein science : a publication of the Protein Society 20100701 7
Many chromatin-associated proteins contain two sequence motifs rich in phenylalanine/tyrosine residues of unknown function. These so-called FYRN and FYRC motifs are also found in transforming growth factor beta regulator 1 (TBRG1)/nuclear interactor of ARF and MDM2 (NIAM), a growth inhibitory protein that also plays a role in maintaining chromosomal stability. We have solved the structure of a fragment of TBRG1, which encompasses both of these motifs. The FYRN and FYRC regions each form part of ...[more]