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Diethyl 6,13-dioxo-5,7,12,13b,13c,14-hexa-hydro-6H,13H-5a,6a,12a,13a-tetra-azabenz[5,6]azuleno[2,1,8-ija]benz[f]azulene-13b,13c-dicarboxyl-ate 1,2-dichloro-ethane solvate.

ABSTRACT: In the title inclusion compound, C(26)H(26)N(4)O(6)·C(2)H(4)Cl(2), the solvent mol-ecule occupies a cavity inside the clip-type mol-ecule which is based on the glycoluril skeleton with two ethyl acetate substituents on the convex face of the glycoluril system. The dihedral angle between the aromatic rings of the host is 43.59 (4)° and the centroid-centroid distance is 6.741 (5) Å. The 1,2-dichloro-etane mol-ecule adopts a gauche conformation enabling it to participate in C-H⋯π inter-actions with the host. The packing motif in the title compound differs from that observed in the crystal structures of the host and in the benzene solvate. The host mol-ecules are linked into tapes by π-π stacking inter-actions (centroid-centroid distance = 3.733 Å) and are further assembled into layers via C-H⋯O inter-actions. One of the ethyl groups is disorded over two positions with site-occupancy factors of 0.702 (14) and 0.298 (14).

SUBMITTER: Liu HX

PROVIDER: S-EPMC2970980 | biostudies-literature |

REPOSITORIES: biostudies-literature

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13b,13c-Di-2-pyridyl-5,7,12,13b,13c,14-hexa-hydro-6H,13H-5a,6a,12a,13a-tetra-azabenz[5,6]azuleno[2,1,8-ija]benz[f]azulene-6,13-dione methanol hemisolvate.

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DNA Methylome and 3D Chromatin Landscape of Cell Types Across the Mouse Brain [12I-13A-13B]

Project description:Illustrating the cellular architecture of the mammalian brain is critical to understanding its diverse functions and complex animal behaviors. With support from NIMH and NINDS as part of the BRAIN Initiative Cell Census Network (BICCN), the Center for Epigenomics of the Mouse Brain Atlas (CEMBA) applied single nucleus methylation sequencing in 117 brain funtional regions across the whole adult male P56 C57BL/6J mouse brain. In each major brain regions, we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster. We integrate the single cell methylome with single cell gene expression and chromatin accessibility profiles from the same brain region to further identify potential enhancers and their corresponding genes for several neuronal cell types. By brain region spacial comparisons, we found spatial specificity among excitatory neuronal clusters within the same cortical layer. We identify brain-region-specific transcription factors that may regulate cortical region development of excitatory neurons. These data define the landscape of cell type and spatial heterogeneity in the mouse brain and the underlining regulatory epigenomic basis.

2023-05-21 | GSE232768 | GEO

2,17-Dichloro-8,9,10,11-tetra-hydro-19H-dibenzo[k,n][1,10,4,7]dioxadiaza-cyclo-penta-decine-7,12(6H,13H)-dione.

Project description:In the crystal structure of the title compound, C(19)H(18)Cl(2)N(2)O(4), N-H?O hydrogen bonds link the mol-ecules into infinite chains along the b axis. The structure also features weak C-H?O and C-H?Cl hydrogen bonds and C-H?? and (lone pair)?? inter-actions [Cl?centroid = 3.5871?(7)?Å]. An intra-molecular N-H?O bond occurs.

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Crystal structure of 15-(naphthalen-1-yl)-7,7a,8,9,10,11-hexa-hydro-6a,12a-(methano-epoxy-methano)-indolizino[2,3-c]quinoline-6,13(5H)-dione.

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Diethyl 7,8-dibromo-4,11-dioxo-11b,11c-dihydro-5H,10H-2-oxa-3a,4a,10a,11a-tetra-azabenz[f]indeno[2,1,7,7a-ija]azulene-11b,11c-dicarboxyl-ate.

Project description:The title compound, C(20)H(20)Br(2)N(4)O(7), is an inter-mediate for mol-ecular clips. The seven- and six-membered rings have chair conformations, while the five-membered rings adopt envelope conformations. In the crystal structure, weak C-H⋯O and C-H⋯Br inter-actions link the mol-ecules into a three-dimensional network. The eth-oxy and ethyl groups are disordered over two orientations, with occupancy ratios of 0.735 (16):0.265 (16) and 0.51 (2):0.49 (2), respectively.

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Project description:In the title mol-ecule, C(24)H(31)N(5)O(6), the two ethyl fragments are each disordered over two conformations [occupancy ratios 0.58 (13)/0.42 (13) and 0.56 (12)/0.44 (12)]. The crystal packing exhibits inter-molecular non-classical C-H⋯O hydrogen bonds and π-π inter-actions between benzene rings [centroid-centroid distances = 3.836 (5) Å].

| S-EPMC2979957 | biostudies-literature

Methyl 5-phenyl-1,2,3,4,4a,5,5a,13c-octahydro-6H-benzo[f]chromeno[3,4-b]indolizine-5a-carboxyl-ate.

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