Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan B
PROVIDER: S-EPMC2974045 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Ramakrishnan Boopathy B Qasba Pradman K PK
Current opinion in structural biology 20100811 5
Cell surface glycans play important cellular functions and are synthesized by glycosyltransferases. Structure and function studies show that the donor sugar specificity of the invertebrate β1,4-N-acetyl-glactosaminyltransferase (β4GalNAc-T) and the vertebrate β1,4-galactosyltransferase I (β4Gal-T1) are related by a single amino acid residue change. Comparison of the catalytic domain crystal structures of the β4Gal-T1 and the α-polypeptidyl-GalNAc-T (αppGalNAc-T) shows that their protein structur ...[more]