Ontology highlight
ABSTRACT:
SUBMITTER: Noris M
PROVIDER: S-EPMC2974386 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Noris Marina M Caprioli Jessica J Bresin Elena E Mossali Chiara C Pianetti Gaia G Gamba Sara S Daina Erica E Fenili Chiara C Castelletti Federica F Sorosina Annalisa A Piras Rossella R Donadelli Roberta R Maranta Ramona R van der Meer Irene I Conway Edward M EM Zipfel Peter F PF Goodship Timothy H TH Remuzzi Giuseppe G
Clinical journal of the American Society of Nephrology : CJASN 20100701 10
<h4>Background and objectives</h4>Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Most childhood cases are caused by Shiga toxin-producing bacteria. The other form, atypical HUS (aHUS), accounts for 10% of cases and has a poor prognosis. Genetic complement abnormalities have been found in aHUS.<h4>Design, setting, participants, and measurements</h4>We screened 273 consecutive patients with aHUS for complement abnormal ...[more]