Ontology highlight
ABSTRACT:
SUBMITTER: Kireev D
PROVIDER: S-EPMC2974617 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Kireev Dmitri D Wigle Tim J TJ Norris-Drouin Jacqueline J Herold J Martin JM Janzen William P WP Frye Stephen V SV
Journal of medicinal chemistry 20101101 21
The malignant brain tumor (MBT) repeat is an important epigenetic-code "reader" and is functionally associated with differentiation, gene silencing, and tumor suppression. (1-3) Small molecule probes of MBT domains should enable a systematic study of MBT-containing proteins and potentially reveal novel druggable targets. We designed and applied a virtual screening strategy that identified potential MBT antagonists in a large database of commercially available compounds. A small set of virtual hi ...[more]