Ontology highlight
ABSTRACT:
SUBMITTER: Cantor KP
PROVIDER: S-EPMC2974691 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cantor Kenneth P KP Villanueva Cristina M CM Silverman Debra T DT Figueroa Jonine D JD Real Francisco X FX Garcia-Closas Monserrat M Malats Nuria N Chanock Stephen S Yeager Meredith M Tardon Adonina A Garcia-Closas Reina R Serra Consol C Carrato Alfredo A Castaño-Vinyals Gemma G Samanic Claudine C Rothman Nathaniel N Kogevinas Manolis M
Environmental health perspectives 20101101 11
<h4>Background</h4>Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.<h4>Objectives</h4>In this study we investigated the combined influence of DBP exposure and polymorphisms in glutathione S-transferase (GSTT1, GSTZ1) and cytochrome P450 (CYP2E1) genes in the metabolic pathways of selected by-products on bladder cancer in a hospital-based case-control study in Spain.<h4>Methods</h4>Average exposures to trihalomethanes (THMs; a surrogate ...[more]