Ontology highlight
ABSTRACT:
SUBMITTER: Wilke RA
PROVIDER: S-EPMC2974901 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Wilke Russell A RA Simpson Robert U RU Mukesh Bickol N BN Bhupathi Satya V SV Dart Richard A RA Ghebranious Nader R NR McCarty Catherine A CA
Pharmacogenomics 20091101 11
<h4>Aims</h4>We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension.<h4>Materials & methods</h4>Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls ...[more]