Ontology highlight
ABSTRACT:
SUBMITTER: Chan J
PROVIDER: S-EPMC2975231 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Chan Jenny J Yamazaki Haruka H Ishiyama Noboru N Seo Min-Duk MD Mal Tapas K TK Michikawa Takayuki T Mikoshiba Katsuhiko K Ikura Mitsuhiko M
The Journal of biological chemistry 20100915 46
The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP(3)R) exhibit distinct IP(3) sensitivities and cooperativities in calcium (Ca(2+)) channel function. The determinants underlying this isoform-specific channel gating mechanism have been localized to the N-terminal suppressor region of IP(3)R. We determined the 1.9 Å crystal structure of the suppressor domain from type 3 IP(3)R (IP(3)R3(SUP), amino acids 1-224) and revealed structural features contributing to isoform-specific func ...[more]