Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.
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ABSTRACT:
SUBMITTER: Padmanabhan K
PROVIDER: S-EPMC2975253 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.
Padmanabhan Krishnan K Urban Nathaniel N NN
Nature neuroscience 20100829 10
Although examples of variation and diversity exist throughout the nervous system, their importance remains a source of debate. Even neurons of the same molecular type have notable intrinsic differences. Largely unknown, however, is the degree to which these differences impair or assist neural coding. We examined the outputs from a single type of neuron, the mitral cells of the mouse olfactory bulb, to identical stimuli and found that each cell's spiking response was dictated by its unique biophy ...[more]
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