Ontology highlight
ABSTRACT:
SUBMITTER: Wauchope OR
PROVIDER: S-EPMC2975515 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Wauchope Orrette R OR Tomney Matthew J MJ Pepper Joseph L JL Korba Brent E BE Seley-Radtke Katherine L KL
Organic letters 20101001 20
Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosi ...[more]