Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B.
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ABSTRACT:
SUBMITTER: Sheppard CL
PROVIDER: S-EPMC2976087 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B.
Sheppard Carmen L CL Pichon Bruno B George Robert C RC Hall Lucinda M C LM
Clinical and vaccine immunology : CVI 20100928 11
Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change. ...[more]
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