Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS.
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SUBMITTER: Sun JR
PROVIDER: S-EPMC2976115 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Overexpression of the adeB gene in clinical isolates of tigecycline-nonsusceptible Acinetobacter baumannii without insertion mutations in adeRS.
Sun Jun-Ren JR Chan Ming-Chin MC Chang Tein-Yao TY Wang Wei-Yao WY Chiueh Tzong-Shi TS
Antimicrobial agents and chemotherapy 20100809 11
Thirteen clinical isolates of multidrug-resistant Acinetobacter baumannii resistant to carbapenems (MRAB-C) with tigecycline nonsusceptibility were collected from individual patients in this study. None of the 13 isolates shared the same strain characteristics in molecular typing. All of them showed increased adeB transcription, as predicted. However, none of these tigecycline-nonsusceptible MRAB-C isolates were found to possess previously known adeRS mutations. Upregulation of adeB transcriptio ...[more]
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