Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.
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ABSTRACT:
SUBMITTER: Young TP
PROVIDER: S-EPMC2976162 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.
Young Thomas P TP Parkin Neil T NT Stawiski Eric E Pilot-Matias Tami T Trinh Roger R Kempf Dale J DJ Norton Michael M
Antimicrobial agents and chemotherapy 20100830 11
Patterns of HIV-1 protease inhibitor (PI) resistance-associated mutations (RAMs) and effects on PI susceptibility associated with the L76V mutation were studied in a large database. Of 20,501 sequences with ≥1 PI RAM, 3.2% contained L76V; L76V was alone in 0.04%. Common partner mutations included M46I, I54V, V82A, I84V, and L90M. L76V was associated with a 2- to 6-fold decrease in susceptibility to lopinavir, darunavir, amprenavir, and indinavir and a 7- to 8-fold increase in susceptibility to a ...[more]
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